# Difference between revisions of "Applied/ACMS/absS16"

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How microbial diversity is generated and maintained is a fundamental ecological question that can be studied through laboratory microcosm experiments and mathematical modeling. We developed a platform for measuring interactions and dynamics in communities of antibiotic producing bacteria and examined patterns of microbial interactions and frequency-dependent selection. We discovered high levels of antibiotic inhibition, high levels of antibiotic degradation, and frequent bistability among pairs of strains. This data led to the theoretical realization that the interplay between antibiotic production and degradation can lead to robust diversity maintenance through simple motifs that contain bistable pairs. Further computer simulations showed that evolution of antibiotic production and degradation capabilities can lead to spontaneous emergence of diversity and complex eco-evolutionary dynamics in simple environments with a single food source. | How microbial diversity is generated and maintained is a fundamental ecological question that can be studied through laboratory microcosm experiments and mathematical modeling. We developed a platform for measuring interactions and dynamics in communities of antibiotic producing bacteria and examined patterns of microbial interactions and frequency-dependent selection. We discovered high levels of antibiotic inhibition, high levels of antibiotic degradation, and frequent bistability among pairs of strains. This data led to the theoretical realization that the interplay between antibiotic production and degradation can lead to robust diversity maintenance through simple motifs that contain bistable pairs. Further computer simulations showed that evolution of antibiotic production and degradation capabilities can lead to spontaneous emergence of diversity and complex eco-evolutionary dynamics in simple environments with a single food source. | ||

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+ | === Atsushi Mochizuki (RIKEN, Japan) === | ||

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+ | ''Dynamics of complex biological systems determined/controlled by minimal subsets of molecules in regulatory networks'' | ||

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+ | Modern biology provides many networks describing regulations between a large number of species of molecules. It is widely believed that the dynamics of molecular activities based on such regulatory networks are the origin of biological functions. In this study we develop a new theory to provide an important aspect of dynamics from information of regulatory linkages alone. We show that the "feedback vertex set" (FVS) of a regulatory network is a set of "determining nodes" of the dynamics. It assures that (i) any long-term dynamical behavior of the whole system, such as steady states, periodic oscillations or quasi-periodic oscillations, can be identified by measurements of a subset of molecules in the network, and that (ii) the subset is determined from the regulatory linkage alone. For example, dynamical attractors possibly generated by a signal transduction network with 113 molecules can be identified by measurement of the activity of only 5 molecules, if the information on the network structure is correct. We also demonstrate that controlling the dynamics of the FVS is sufficient to switch the dynamics of the whole system from one attractor to others, distinct from the original. | ||

+ | |||

+ | Further Reading: | ||

+ | |||

+ | Mochizuki A., Fiedler B., Kurosawa G. and Saito D. (2013) Dynamics and control at feedback vertex sets. J. Theor. Biol. 335: 130-146. | ||

=== Randall Kamien (U Penn) === | === Randall Kamien (U Penn) === | ||

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This talk is based on a recently proposed flux vector splitting method for the Euler equations which, compared to existing splitting methods, has some distinctive advantages, such as exact recognition of stationary isolated contact/shear waves, simplicity, robustness and efficiency. Distinguishing features of the new flux splitting approach are: complete separation of pressure from advection terms and identification of a reduced pressure system that furnishes all required information for constructing the full numerical flux in a simple manner. The resulting first-order method was originally proposed for the 1D Euler equations for ideal gases. In this talk I will first present the scheme as applied to the 3D Euler equations with general equation of state. Then I shall describe its extension to high-order of accuracy in both space and time, on unstructured meshes, using the ADER approach. Performance of the resulting method is illustrated through some carefully chosen test problems. I finish this presentation by mentioning extensions of this novel flux splitting approach to other hyperbolic systems, such as the MHD equations and the Baer-Nunziato equations for compressible multiphase flows. | This talk is based on a recently proposed flux vector splitting method for the Euler equations which, compared to existing splitting methods, has some distinctive advantages, such as exact recognition of stationary isolated contact/shear waves, simplicity, robustness and efficiency. Distinguishing features of the new flux splitting approach are: complete separation of pressure from advection terms and identification of a reduced pressure system that furnishes all required information for constructing the full numerical flux in a simple manner. The resulting first-order method was originally proposed for the 1D Euler equations for ideal gases. In this talk I will first present the scheme as applied to the 3D Euler equations with general equation of state. Then I shall describe its extension to high-order of accuracy in both space and time, on unstructured meshes, using the ADER approach. Performance of the resulting method is illustrated through some carefully chosen test problems. I finish this presentation by mentioning extensions of this novel flux splitting approach to other hyperbolic systems, such as the MHD equations and the Baer-Nunziato equations for compressible multiphase flows. | ||

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## Revision as of 16:20, 6 April 2016

## Contents

- 1 ACMS Abstracts: Spring 2016
- 1.1 Stefan Llewellyn Smith (UCSD)
- 1.2 Tom Solomon (Bucknell)
- 1.3 Daniele Cappelletti (KU)
- 1.4 Lihui Chai (UCSB)
- 1.5 Alejandro Roldan-Alzate (UW)
- 1.6 Yachun Li (SJTU)
- 1.7 Peter Hinow (UW-Milwaukee)
- 1.8 Jorn Dunkel (MIT)
- 1.9 Kalin Vetsigian (UW)
- 1.10 Atsushi Mochizuki (RIKEN, Japan)
- 1.11 Randall Kamien (U Penn)
- 1.12 Eleuterio Toro (U Trento)

# ACMS Abstracts: Spring 2016

### Stefan Llewellyn Smith (UCSD)

*Hollow vortices*

Hollow vortices are vortices whose interior is at rest. They posses vortex sheets on their boundaries and can be viewed as a desingularization of point vortices. After giving a history of point vortices, we obtain exact solutions for hollow vortices in linear and nonlinear strain and examine the properties of streets of hollow vortices. The former can be viewed as a canonical example of a hollow vortex in an arbitrary flow, and its stability properties depend on a single non-dimensional parameter. In the latter case, we reexamine the hollow vortex street of Baker, Saffman and Sheffield and examine its stability to arbitrary disturbances, and then investigate the double hollow vortex street. Implications and extensions of this work are discussed.

### Tom Solomon (Bucknell)

*Experimental studies of reaction front barriers in laminar flows*

We present studies of the effects of vortex-dominated fluid flows on the motion of reaction fronts produced by the excitable Belousov-Zhabotinsky reaction. The results of these experiments have applications for advection-reaction-diffusion dynamics in a wide range of systems including microfluidic chemical reactors, cellular-scale processes in biological systems, and blooms of phytoplankton in the oceans. To predict the behavior of reaction fronts, we adapt tools used to describe passive mixing.In particular, the concept of an invariant manifold is extended to account for reactive burning. Burning invariant manifolds (BIMs) are predicted as one-way barriers that locally block the motion of reaction fronts. These ideas are tested and illustrated experimentally in a chain of alternating vortices, a spatially-random flow, vortex flows with imposed winds, and a three-dimensional, nested vortex flow. We also discuss the applicability of BIM theory to the motion of bacteria in fluid flows.

### Daniele Cappelletti (KU)

*Deterministic and stochastic reaction networks*

Mathematical models of biochemical reaction networks are of great interest for the analysis of experimental data and theoretical biochemistry. Moreover, such models can be applied in a broader framework than that provided by biology. The classical deterministic model of a reaction network is a system of ordinary differential equations, and the standard stochastic model is a continuous-time Markov chain. A relationship between the dynamics of the two models can be found for compact time intervals, while the asymptotic behaviours of the two models may differ greatly. I will give an overview of these problems and show some recent development.

### Lihui Chai (UCSB)

*Semiclassical limit of the Schrödinger-Poisson-Landau-Lifshitz-Gilbert system*

The Schrödinger-Poisson-Landau-Lifshitz-Gilbert (SPLLG) system is an effective microscopic model that describes the coupling between conduction electron spins and the magnetization in ferromagnetic materials. This system has been used in connection to the study of spin transfer and magnetization reversal in ferromagnetic materials. In this paper, we rigorously derive the Vlasov-Poisson-Landau-Lifshitz-Glibert system as the semiclassical limit of SPLLG. The major difficulties come from the presence of the spin-magnetization coupling and the discontinuities of the magnetization at the boundary of the material. To overcome these difficulties, we first take the semiclassical limit (vanishing Planck constant) of a smoothed SPLLG system, and then the limit of vanishing smoothing parameter. As a byproduct, we prove the local existence and uniqueness of classical solutions to the smoothed SPLLG system.

### Alejandro Roldan-Alzate (UW)

*Non–invasive patient-specific cardiovascular fluid dynamics*

Comprehensive characterization and quantification of blood flow is essential for understanding the function of the cardiovascular system under normal and diseased conditions. This provides important information not only for the diagnosis and treatment planning of different cardiovascular diseases but also for the design of cardiovascular devices. However, the anatomical complexity and multidirectional nature of physiological and pathological hemodynamics makes non-invasive characterization and quantification of blood flow difficult and challenging. Doppler ultrasound, a standard imaging technique, is limited to providing information on large vessels and calculating instantaneous average flow within the cardiac cycle. Magnetic resonance imaging (MRI) is increasingly being used for fluid dynamics analyses of cardiovascular diseases, including pulmonary arterial hypertension, portal hypertension and congenital heart diseases. Although two-dimensional (2D) phase contrast (PC) magnetic resonance imaging (MRI) measures velocity across a plane, it is still limited in its ability to fully characterize these complex flow systems. Four- dimensional (4D) flow MRI obtains velocity measurements in three dimensions throughout the entire cardiac cycle. Several attempts have been made to non-invasively characterize the blood flow dynamics of different cardiovascular diseases using the combination of medical imaging and computational fluid dynamics modeling (CFD). Idealized geometries, as well as patient-specific anatomies, have been used for computational simulations, which have improved the understanding of the fluid dynamics phenomena in different vascular territories. While CFD modeling can provide powerful insights and the potential for simulating different physiological and pathological conditions in the cardiovascular system, it is currently not reliable for use in clinical care. Based on different studies, additional work is needed to verify the accuracy of current CFD approaches or identify and address current shortcomings. The overall purpose of this research is to develop, implement and validate non-invasive flow analysis methodologies to assess cardiovascular flow dynamics, using a combination of 4D flow MRI, numerical simulations and patient-specific physical models. In this seminar, multidisciplinary work will be presented first, where different cardiovascular pathologies have been studied, such as congenital heart disease and portal hypertension using in vivo, in vitro and computational models. Second, some advances will be presented and a future outlook into the valuable contribution of engineering in the medical imaging and diagnostic technology will be provided.

### Yachun Li (SJTU)

*Vanishing viscosity limit of the compressible Isentropic Navier-Stokes equations with degenerate viscosities*

In this talk we first establish the local-in-time well-posedness of the unique regular solution to the compressible isentropic Navier-Stokes equations with density-dependent viscosities in a power law and with vacuum appearing in some open set or at the far field, then after establishing uniform energy-type estimates with respect to the viscosity coefficients for the regular solutions we prove the convergence of the regular solution of the Navier-Stokes equations to that of the Euler equations with arbitrarily large data containing vacuum.

### Peter Hinow (UW-Milwaukee)

*Aspects of mathematical modeling of drug delivery*

There are a variety of devices for the delivery of pharmaceutical substances, tablets of course being the most prominent. Pharmaceutical scientists and physicians have formulated goals, such as release of a drug in a controlled fashion over an extended period of time or the targeted delivery of a drug to a specific site in a patient’s body. Since experiments with these delivery devices can be costly and sometimes only partially conclusive, mathematical modeling plays a considerable role in understanding the mechanisms behind experimental release profiles, and in developing delivery systems. We present our works on drug delivery by matrix tablets and targeted drug delivery to the brain. This is joint work with Ami Radunskaya (Department of Mathematics, Pomona College, Claremont, CA) and Ian Tucker (School of Pharmacy, University of Otago, Dunedin, New Zealand), and has been supported by NSF grants DMS 1016214 and DMS 1016136 .

### Jorn Dunkel (MIT)

*Pattern formation in soft and biological matter*

Identifying the generic ordering principles that govern multicellular and intracellular dynamics is essential for separating universal from system-specific aspects in the physics of living organisms. In this talk, we will survey and compare three recently proposed nonlinear continuum theories, which aim to describe pattern formation and topological defect structures in soft elastic bilayer materials, dense bacterial suspensions and ATP-driven active liquid crystals. We will discuss the phase diagrams of the three models, relate their predictions to experiments, and emphasize the underlying universality ideas. The good agreement with experimental data supports the idea that non-equilibrium pattern formation in a broad range of soft and active matter systems can be described effectively within the same class of higher-order partial differential equations.

### Kalin Vetsigian (UW)

*Interactions and dynamics in communities of antibiotic producing bacteria*

How microbial diversity is generated and maintained is a fundamental ecological question that can be studied through laboratory microcosm experiments and mathematical modeling. We developed a platform for measuring interactions and dynamics in communities of antibiotic producing bacteria and examined patterns of microbial interactions and frequency-dependent selection. We discovered high levels of antibiotic inhibition, high levels of antibiotic degradation, and frequent bistability among pairs of strains. This data led to the theoretical realization that the interplay between antibiotic production and degradation can lead to robust diversity maintenance through simple motifs that contain bistable pairs. Further computer simulations showed that evolution of antibiotic production and degradation capabilities can lead to spontaneous emergence of diversity and complex eco-evolutionary dynamics in simple environments with a single food source.

### Atsushi Mochizuki (RIKEN, Japan)

*Dynamics of complex biological systems determined/controlled by minimal subsets of molecules in regulatory networks*

Modern biology provides many networks describing regulations between a large number of species of molecules. It is widely believed that the dynamics of molecular activities based on such regulatory networks are the origin of biological functions. In this study we develop a new theory to provide an important aspect of dynamics from information of regulatory linkages alone. We show that the "feedback vertex set" (FVS) of a regulatory network is a set of "determining nodes" of the dynamics. It assures that (i) any long-term dynamical behavior of the whole system, such as steady states, periodic oscillations or quasi-periodic oscillations, can be identified by measurements of a subset of molecules in the network, and that (ii) the subset is determined from the regulatory linkage alone. For example, dynamical attractors possibly generated by a signal transduction network with 113 molecules can be identified by measurement of the activity of only 5 molecules, if the information on the network structure is correct. We also demonstrate that controlling the dynamics of the FVS is sufficient to switch the dynamics of the whole system from one attractor to others, distinct from the original.

Further Reading:

Mochizuki A., Fiedler B., Kurosawa G. and Saito D. (2013) Dynamics and control at feedback vertex sets. J. Theor. Biol. 335: 130-146.

### Randall Kamien (U Penn)

*Liquid crystals and their (algebraic) topology*

Liquid Crystals, the materials in your iPhone, are complex materials with varying degrees of internal order. I will discuss and demonstrate how algebraic topology can be used to identify and characterize long-lived configurations. I will also describe how conic sections naturally arise in these structures as intersections of simple polynomials.

### Eleuterio Toro (U Trento)

*A flux splitting approach to a class of hyperbolic systems*

This talk is based on a recently proposed flux vector splitting method for the Euler equations which, compared to existing splitting methods, has some distinctive advantages, such as exact recognition of stationary isolated contact/shear waves, simplicity, robustness and efficiency. Distinguishing features of the new flux splitting approach are: complete separation of pressure from advection terms and identification of a reduced pressure system that furnishes all required information for constructing the full numerical flux in a simple manner. The resulting first-order method was originally proposed for the 1D Euler equations for ideal gases. In this talk I will first present the scheme as applied to the 3D Euler equations with general equation of state. Then I shall describe its extension to high-order of accuracy in both space and time, on unstructured meshes, using the ADER approach. Performance of the resulting method is illustrated through some carefully chosen test problems. I finish this presentation by mentioning extensions of this novel flux splitting approach to other hyperbolic systems, such as the MHD equations and the Baer-Nunziato equations for compressible multiphase flows.