# Probability Seminar

# Spring 2014

Thursdays in 901 Van Vleck Hall at 2:25 PM, unless otherwise noted.

**
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## Thursday, January 23, CANCELED--NO SEMINAR

## Thursday, February 6, Jay Newby, Mathematical Biosciences Institute

Title: Applications of large deviation theory in neuroscience

Abstract: The membrane voltage of a neuron is modeled with a piecewise deterministic stochastic process. The membrane voltage changes deterministically while the population of open ion channels, which allow current to flow across the membrane, is constant. Ion channels open and close randomly, and the transition rates depend on voltage, making the process nonlinear. In the limit of infinite transition rates, the process becomes deterministic. The deterministic process is the well known Morris-Lecar model. Under certain conditions, the deterministic process has one stable fixed point and is excitable. An excitable event, called an action potential, is a single large transient spike in voltage that eventually returns to the stable steady state. I will discuss recent development of large deviation theory to study noise induced action potentials.

## Thursday, February 13, Diane Holcomb, UW-Madison

Title: Large deviations for point process limits of random matrices.

Abstract: The Gaussian Unitary ensemble (GUE) is one of the most studied Hermitian random matrix model. When appropriately rescaled the eigenvalues in the bulk of the spectrum converge to a translation invariant limiting point process called the Sine process. On large intervals one expects the Sine process to have a number of points that is roughly the length of the interval times a fixed constant (the density of the process). We solve the large deviation problem which asks about the asymptotic probability of seeing a different density in a large interval as the size of the interval tends to infinity. Our proof works for a one-parameter family of models called beta-ensembles which contain the Gaussian orthogonal, unitary and symplectic ensembles as special cases.

## Thursday, February 20, TBA

## Thursday, February 27, Jack Hanson, Indiana University Bloomington

Title: TBA

Abstract: TBA

## Thursday, March 6, TBA

## Thursday, March 13, TBA

## Thursday, March 20, No Seminar due to Spring Break

## Thursday, March 27, Cécile Ané, UW-Madison Department of Statistics

Title: ** Application of a birth-death process to model gene gains and losses on a phylogenetic tree **

## Thursday, April 3, TBA

## Thursday, April 10, Dan Romik UC-Davis

## Thursday, April 17, TBA

## Thursday, April 24, TBA

## Thursday, May 1, TBA

## Thursday, May 8, TBA